Diazepam binding inhibitor

DBI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FJ9, 2CB8
Identifiers
Aliases	DBI, ACBD1, ACBP, CCK-RP, EP, Diazepam binding inhibitor, diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein), diazepam binding inhibitor, acyl-CoA binding protein
External IDs	OMIM: 125950; MGI: 94865; HomoloGene: 39086; GeneCards: DBI; OMA:DBI - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	119,372,550 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	120,048,808 bp
RNA expression pattern
	Top expressed in
	vulva; ; mucosa of transverse colon; ; gingival epithelium; ; sperm; ; skin of thigh; ; oral cavity; ; mucosa of pharynx; ; human penis; ; skin of hip; ; ventricular zone;
	Top expressed in
	optic nerve; ; brown adipose tissue; ; white adipose tissue; ; right kidney; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; lactiferous gland; ; medial ganglionic eminence; ; ventricular zone; ; Epithelium of choroid plexus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	benzodiazepine receptor binding; lipid binding; long-chain fatty acyl-CoA binding; fatty-acyl-CoA binding; protein dimerization activity;
Cellular component	Golgi apparatus; perinuclear endoplasmic reticulum; extracellular exosome; endoplasmic reticulum; endoplasmic reticulum lumen;
Biological process	protein palmitoylation; phosphatidylcholine acyl-chain remodeling; acyl-CoA metabolic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	1622
	13167
	ENSG00000155368
	ENSMUSG00000026385
	P07108
	P31786
NM_001079862; NM_001079863; NM_001178017; NM_001178041; NM_001178042;
	NM_001178043; NM_001282633; NM_001282634; NM_001282635; NM_001282636; NM_020548; NM_001352432
	NM_001037999; NM_007830
NP_001073331; NP_001073332; NP_001171488; NP_001171512; NP_001171513;
	NP_001171514; NP_001269562; NP_001269563; NP_001269564; NP_001269565; NP_065438; NP_001339361
	NP_001033088; NP_031856
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA-binding protein in humans belongs to the family of Acyl-CoA-binding proteins.

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.