DBP (gene)

DBP
Identifiers
Aliases	DBP, DABP, D-box binding PAR bZIP transcription factor, taxREB302
External IDs	OMIM: 124097; MGI: 94866; HomoloGene: 1035; GeneCards: DBP; OMA:DBP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,637,379 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,359,627 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right adrenal cortex; ; right frontal lobe; ; caudate nucleus; ; nucleus accumbens; ; prefrontal cortex; ; putamen; ; left adrenal cortex; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	retinal pigment epithelium; ; Epithelium of choroid plexus; ; iris; ; olfactory tubercle; ; ankle; ; vestibular membrane of cochlear duct; ; nucleus accumbens; ; lacrimal gland; ; suprachiasmatic nucleus; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; liver development; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; rhythmic process; circadian rhythm; multicellular organism development; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1628
	13170
	ENSG00000105516
	ENSMUSG00000059824
	Q10586
	Q60925
	NM_001352
	NM_016974
	NP_001343
	NP_058670
	Wikidata
View/Edit Human	View/Edit Mouse

D site of albumin promoter (albumin D-box) binding protein, also known as DBP, is a protein which in humans is encoded by the DBP gene.

DBP is a member of the PAR bZIP (Proline and Acidic amino acid-Rich basic leucine ZIPper) transcription factor family. DBP binds to an upstream promoter in the insulin gene.

DBP was shown to follow a stringent circadian rhythm; both the levels of protein and mRNA are almost non-detectable in the morning, but reach their maximum level in the evening.