DBR1

DBR1
Identifiers
Aliases	DBR1, debranching RNA lariats 1
External IDs	OMIM: 607024; MGI: 1931520; HomoloGene: 9428; GeneCards: DBR1; OMA:DBR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	138,174,921 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	99,466,554 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Achilles tendon; ; tendon of biceps brachii; ; amniotic fluid; ; germinal epithelium; ; gonad; ; epithelium of nasopharynx; ; ganglionic eminence; ; islet of Langerhans; ; ventricular zone;
	Top expressed in
	primitive streak; ; epiblast; ; abdominal wall; ; hair follicle; ; medial ganglionic eminence; ; trigeminal ganglion; ; maxillary prominence; ; motor neuron; ; endothelial cell of lymphatic vessel; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; RNA lariat debranching enzyme activity; hydrolase activity, acting on ester bonds; metal ion binding; RNA binding;
Cellular component	nucleus; nucleoplasm;
Biological process	RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; mRNA processing; RNA phosphodiester bond hydrolysis, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	51163
	83703
	ENSG00000138231
	ENSMUSG00000032469
	Q9UK59
	Q923B1
	NM_016216
	NM_031403; NM_001368298
	NP_057300
	NP_113580; NP_001355227
	Wikidata
View/Edit Human	View/Edit Mouse

Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.

The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM]