DCLK1

DCLK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MFW, 1MG4, 1UF0
Identifiers
Aliases	DCLK1, CL1, CLICK1, DCAMKL1, DCDC3A, DCLK, doublecortin like kinase 1
External IDs	OMIM: 604742; MGI: 1330861; HomoloGene: 130530; GeneCards: DCLK1; OMA:DCLK1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	36,131,382 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	55,446,489 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; frontal pole; ; Brodmann area 10; ; Brodmann area 23; ; pars reticulata; ; pars compacta; ; occipital lobe; ; middle temporal gyrus; ; superior vestibular nucleus; ; primary visual cortex;
	Top expressed in
	stria vascularis; ; Rostral migratory stream; ; piriform cortex; ; vestibular sensory epithelium; ; habenula; ; visual cortex; ; superior frontal gyrus; ; primary visual cortex; ; primary motor cortex; ; prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; ATP binding; protein serine/threonine kinase activity;
Cellular component	integral component of plasma membrane; intracellular anatomical structure; postsynaptic density;
Biological process	cell differentiation; axonogenesis; dendrite morphogenesis; phosphorylation; response to virus; neuron migration; nervous system development; multicellular organism development; endosomal transport; protein phosphorylation; central nervous system development; brain development; axon extension; forebrain development; central nervous system projection neuron axonogenesis; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction; neuron projection morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9201
	13175
	ENSG00000133083
	ENSMUSG00000027797
	O15075
	Q9JLM8
NM_001195415; NM_001195416; NM_001195430; NM_004734; NM_001330071;
	NM_001330072
NM_001111051; NM_001111052; NM_001111053; NM_001195538; NM_001195539;
	NM_001195540; NM_019978; NM_001357466; NM_001357468; NM_001357469; NM_001357475; NM_001357476
NP_001182344; NP_001182345; NP_001182359; NP_001317000; NP_001317001;
	NP_004725
NP_001104521; NP_001104522; NP_001104523; NP_001182467; NP_001182468;
	NP_001182469; NP_064362; NP_001344395; NP_001344397; NP_001344398; NP_001344404; NP_001344405
	Wikidata
View/Edit Human	View/Edit Mouse

Doublecortin-like kinase protein 1 (DCLK1) is an enzyme that in humans is encoded by the DCLK1 gene. Its C-terminal domain in rats is expressed independently from an alternative transcript, cpg16, and can function alone as a serine/threonine protein kinase that is cyclic AMP dependent.

DCLK1 expression is a marker for tuft cells, a type of chemosensory cell of the intestinal epithelium.