DCLRE1A

DCLRE1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B87, 5AHR
Identifiers
Aliases	DCLRE1A, PSO2, SNM1, SNM1A, DNA cross-link repair 1A
External IDs	OMIM: 609682; MGI: 1930042; HomoloGene: 8920; GeneCards: DCLRE1A; OMA:DCLRE1A - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	113,854,383 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	56,536,675 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; testicle; ; ventricular zone; ; ganglionic eminence; ; tendon of biceps brachii; ; islet of Langerhans; ; germinal epithelium; ; epithelium of nasopharynx; ; mononuclear cell;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; zygote; ; tail of embryo; ; genital tubercle; ; fetal liver hematopoietic progenitor cell; ; spermatocyte; ; left lobe of liver; ; lumbar subsegment of spinal cord; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	5'-3' exodeoxyribonuclease activity; damaged DNA binding;
Cellular component	fibrillar center; nucleus; nucleoplasm;
Biological process	cellular response to DNA damage stimulus; cell cycle; double-strand break repair via nonhomologous end joining; interstrand cross-link repair; protection from non-homologous end joining at telomere; cell division; nucleic acid phosphodiester bond hydrolysis; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	9937
	55947
	ENSG00000198924
	ENSMUSG00000025077
	Q6PJP8
	Q9JIC3
	NM_001271816; NM_014881
	NM_018831; NM_001360437; NM_001360438; NM_001360439
	NP_001258745; NP_055696
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM]