DCLRE1B

DCLRE1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BUA, 5AHO
Identifiers
Aliases	DCLRE1B, APOLLO, SNM1B, SNMIB, DNA cross-link repair 1B
External IDs	OMIM: 609683; MGI: 2156057; HomoloGene: 32553; GeneCards: DCLRE1B; OMA:DCLRE1B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	113,914,086 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	103,716,760 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; ganglionic eminence; ; ventricular zone; ; monocyte; ; skin of hip; ; testicle; ; granulocyte; ; bone marrow; ; trabecular bone;
	Top expressed in
	granulocyte; ; blood; ; otic vesicle; ; cumulus cell; ; yolk sac; ; endocardial cushion; ; external carotid artery; ; abdominal wall; ; ventricular zone; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	5'-3' exonuclease activity; 5'-3' exodeoxyribonuclease activity; damaged DNA binding; protein binding; nuclease activity; exonuclease activity; hydrolase activity; protein homodimerization activity; protein-containing complex binding;
Cellular component	cytoplasm; centrosome; chromosome; microtubule organizing center; telomere; cytoskeleton; nucleus; nucleoplasm; nuclear body;
Biological process	cell cycle checkpoint signaling; protection from non-homologous end joining at telomere; telomeric 3' overhang formation; cellular response to DNA damage stimulus; double-strand break repair via nonhomologous end joining; telomere maintenance; telomeric loop formation; DNA repair; nucleic acid phosphodiester bond hydrolysis; telomere maintenance via telomere lengthening; telomere capping; interstrand cross-link repair; mitotic cell cycle checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	64858
	140917
	ENSG00000118655
	ENSMUSG00000027845
	Q9H816
	Q8C7W7
	NM_022836; NM_001319946; NM_001319947; NM_001363690; NM_001363691
	NM_001025312; NM_133865
	NP_001306875; NP_001306876; NP_073747; NP_001350619; NP_001350620
	NP_001020483; NP_598626
	Wikidata
View/Edit Human	View/Edit Mouse

DNA cross-link repair 1B protein is a protein that in humans is encoded by the DCLRE1B gene.

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM]