DCP1A

DCP1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WX3, 4B6H
Identifiers
Aliases	DCP1A, HSA275986, Nbla00360, SMAD4IP1, SMIF, decapping mRNA 1A
External IDs	OMIM: 607010; MGI: 1923151; HomoloGene: 10178; GeneCards: DCP1A; OMA:DCP1A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	53,347,586 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,249,020 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; cartilage tissue; ; testicle; ; Achilles tendon; ; gonad; ; sural nerve; ; tibialis anterior muscle; ; buccal mucosa cell; ; islet of Langerhans;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; medullary collecting duct; ; tail of embryo; ; saccule; ; otic vesicle; ; genital tubercle; ; otic placode; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity; enzyme activator activity; protein binding; mRNA binding; hydrolase activity; identical protein binding; kinesin binding;
Cellular component	cytoplasm; cytosol; membrane; nucleus; P-body; cytoplasmic ribonucleoprotein granule;
Biological process	positive regulation of catalytic activity; deadenylation-independent decapping of nuclear-transcribed mRNA; protein localization to cytoplasmic stress granule; regulation of mRNA stability; deadenylation-dependent decapping of nuclear-transcribed mRNA; exonucleolytic catabolism of deadenylated mRNA; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
	Sources:Amigo / QuickGO
Orthologs
	55802
	75901
	ENSG00000272886
	ENSMUSG00000021962
	Q9NPI6
	Q91YD3
	NM_018403; NM_001290204; NM_001290205; NM_001290206; NM_001290207
	NM_133761
	NP_001277133; NP_001277134; NP_001277135; NP_001277136; NP_060873
	NP_598522
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.