DCPS (gene)

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Scavenger mRNA decapping enzyme (DcpS) N-terminal
Scavenger mRNA decapping enzyme (DcpS) N-terminal
	crystal structure of mrna decapping enzyme (dcps) from mus musculus at 1.83 a resolution
Identifiers
Symbol	DcpS
Pfam	PF05652
InterPro	IPR008594
SCOP2	1st4 / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

DCPS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ST0, 1ST4, 1XML, 1XMM, 3BL7, 3BL9, 3BLA, 4QDE, 4QDV, 4QEB
Identifiers
Aliases	DCPS, DCS1, HINT-5, HINT5, HSL1, ARS, HSPC015, decapping enzyme, scavenger
External IDs	OMIM: 610534; MGI: 1916555; HomoloGene: 32202; GeneCards: DCPS; OMA:DCPS - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	126,350,005 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	35,087,357 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; oocyte; ; muscle of thigh; ; granulocyte; ; secondary oocyte; ; gallbladder; ; gonad; ; mucosa of transverse colon; ; stromal cell of endometrium; ; spleen;
	Top expressed in
	yolk sac; ; ventricular zone; ; epiblast; ; embryo; ; otic placode; ; embryo; ; endocardial cushion; ; medial ganglionic eminence; ; right kidney; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	m7G(5')pppN diphosphatase activity; protein binding; hydrolase activity; RNA 7-methylguanosine cap binding; exoribonuclease activity;
Cellular component	cytoplasm; mitochondrion; nucleus; nucleoplasm; P-body; cytosol;
Biological process	mRNA cis splicing, via spliceosome; negative regulation of programmed cell death; mRNA processing; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; cellular response to menadione; RNA splicing; exonucleolytic catabolism of deadenylated mRNA; RNA phosphodiester bond hydrolysis, exonucleolytic; deadenylation-dependent decapping of nuclear-transcribed mRNA;
	Sources:Amigo / QuickGO
Orthologs
	28960
	69305
	ENSG00000110063
	ENSMUSG00000032040
	Q96C86
	Q9DAR7
	NM_014026; NM_001350236
	NM_027030
	NP_054745; NP_001337165
	NP_081306
	Wikidata
View/Edit Human	View/Edit Mouse

Scavenger mRNA decapping enzyme C-term binding

Identifiers

Symbol

DcpS_C

Pfam clan

1st4 / SCOPe / SUPFAM

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene.

The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP). The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence in its C-terminal domain, with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.