DCTN3

DCTN3
Identifiers
Aliases	DCTN3, DCTN-22, DCTN22, dynactin subunit 3
External IDs	OMIM: 607387; MGI: 1859251; HomoloGene: 5233; GeneCards: DCTN3; OMA:DCTN3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	34,620,523 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,723,170 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prefrontal cortex; ; ventricular zone; ; right frontal lobe; ; anterior pituitary; ; right hemisphere of cerebellum; ; Brodmann area 9; ; nucleus accumbens; ; muscle of thigh; ; skin of leg;
	Top expressed in
	saccule; ; medial ganglionic eminence; ; otic vesicle; ; otic placode; ; superior frontal gyrus; ; facial motor nucleus; ; right kidney; ; primary visual cortex; ; motor neuron; ; choroid plexus of fourth ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; protein binding;
Cellular component	cytoplasm; centrosome; dynactin complex; spindle; chromosome; microtubule organizing center; microtubule associated complex; midbody; perinuclear region of cytoplasm; cleavage furrow; chromosome, centromeric region; cytoskeleton; kinetochore; nucleolus; cytosol; microtubule;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; cell division; endoplasmic reticulum to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; microtubule-based process; cell cycle; ciliary basal body-plasma membrane docking; mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; cytoskeleton-dependent cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	11258
	53598
	ENSG00000137100
	ENSMUSG00000028447
	O75935
	Q9Z0Y1
	NM_024348; NM_001281425; NM_001281426; NM_001281427; NM_007234
	NM_001159565; NM_016890
	NP_001268354; NP_001268355; NP_001268356; NP_009165; NP_077324
	NP_001153037; NP_058586
	Wikidata
View/Edit Human	View/Edit Mouse

Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.