DCTN5

DCTN5
Identifiers
Aliases	DCTN5, dynactin subunit 5
External IDs	OMIM: 612962; MGI: 1891689; HomoloGene: 10998; GeneCards: DCTN5; OMA:DCTN5 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	23,677,472 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	121,748,267 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; rectum; ; stromal cell of endometrium; ; smooth muscle tissue; ; monocyte; ; mucosa of esophagus; ; ganglionic eminence; ; lymph node; ; epithelium of colon; ; mucosa of transverse colon;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; right kidney; ; granulocyte; ; superior frontal gyrus; ; medial ganglionic eminence; ; yolk sac; ; pituitary gland; ; tail of embryo; ; cumulus cell; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; centrosome; nuclear membrane; chromosome, centromeric region; cytoskeleton; kinetochore; nucleoplasm; chromosome;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; aorta development; ventricular septum development; antigen processing and presentation of exogenous peptide antigen via MHC class II; coronary vasculature development;
	Sources:Amigo / QuickGO
Orthologs
	84516
	59288
	ENSG00000166847
	ENSMUSG00000030868
	Q9BTE1
	Q9QZB9
	NM_001199011; NM_001199743; NM_032486
	NM_021608
	NP_001185940; NP_001186672; NP_115875
	NP_067621
	Wikidata
View/Edit Human	View/Edit Mouse

Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene.

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.