DDT (gene)

DDT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Q3F, 3KAN, 1DPT
Identifiers
Aliases	DDT, DDCT, D-dopachrome tautomerase, MIF-2, MIF2, D-DT
External IDs	OMIM: 602750; MGI: 1298381; HomoloGene: 1038; GeneCards: DDT; OMA:DDT - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,979,828 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,609,248 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; body of pancreas; ; human kidney; ; apex of heart; ; body of stomach; ; left ventricle; ; fundus; ; olfactory zone of nasal mucosa; ; right adrenal gland;
	Top expressed in
	right kidney; ; proximal tubule; ; spermatocyte; ; yolk sac; ; human kidney; ; embryo; ; testicle; ; white adipose tissue; ; epiblast; ; liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dopachrome isomerase activity; D-dopachrome decarboxylase activity; lyase activity; cytokine receptor binding; phenylpyruvate tautomerase activity;
Cellular component	cytoplasm; extracellular exosome; extracellular space;
Biological process	melanin biosynthetic process; negative regulation of macrophage chemotaxis; positive regulation of tumor necrosis factor production; positive regulation of inflammatory response; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	1652
	13202
	ENSG00000099977; ENSG00000275003
	ENSMUSG00000001666
	P30046
	O35215
	NM_001084392; NM_001355; NM_001381852; NM_001397485
	NM_010027
	NP_001077861; NP_001346; NP_001368781
	NP_034157
	Wikidata
View/Edit Human	View/Edit Mouse

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.