DDX11

DDX11
Identifiers
Aliases	DDX11, CHL1, CHLR1, KRG2, WABS, DEAD/H-box helicase 11
External IDs	OMIM: 601150; MGI: 2443590; HomoloGene: 68973; GeneCards: DDX11; OMA:DDX11 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	31,104,799 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	66,459,169 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; body of pancreas; ; left ovary; ; body of uterus; ; right ovary; ; apex of heart; ; lymph node; ; left testis; ; ventricular zone; ; spleen;
	Top expressed in
	primary oocyte; ; hand; ; spermatocyte; ; secondary oocyte; ; Paneth cell; ; zygote; ; epiblast; ; ventricular zone; ; tail of embryo; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	4 iron, 4 sulfur cluster binding; nucleotide binding; helicase activity; iron-sulfur cluster binding; metal ion binding; single-stranded DNA binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; protein binding; RNA binding; nucleic acid binding; double-stranded DNA binding; hydrolase activity; ATP binding; DNA binding; chromatin binding; DNA replication origin binding; single-stranded RNA binding; DNA helicase activity; ATP-dependent activity, acting on DNA; ATP-dependent activity, acting on RNA; triplex DNA binding; G-quadruplex DNA binding;
Cellular component	nucleolus; extracellular exosome; nucleus; spindle pole; fibrillar center; nucleoplasm; chromosome; cytoplasm; centrosome; microtubule organizing center; cytoskeleton; midbody; mitotic cohesin complex; Ctf18 RFC-like complex;
Biological process	sister chromatid cohesion; IRE1-mediated unfolded protein response; viral process; nucleobase-containing compound metabolic process; DNA replication; DNA repair; transcription, DNA-templated; regulation of transcription, DNA-templated; cellular response to DNA damage stimulus; multicellular organism development; replication fork processing; positive regulation of endodeoxyribonuclease activity; negative regulation of protein binding; DNA duplex unwinding; positive regulation of chromatin binding; G-quadruplex DNA unwinding; positive regulation of sister chromatid cohesion; cellular response to hydroxyurea; cellular response to cisplatin; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; cellular response to bleomycin; nucleolar chromatin organization; positive regulation of double-strand break repair; establishment of sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	1663
	320209
	ENSG00000013573
	ENSMUSG00000035842
	Q96FC9
	Q6AXC6
NM_001257144; NM_001257145; NM_004399; NM_030653; NM_030655;
	NM_152438
	NM_001003919; NM_001348292
	NP_001244073; NP_001244074; NP_004390; NP_085911; NP_689651
	NP_001003919; NP_001335221
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent DNA/RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene. DDX11 is found within chromosome 12’s repetitive region. Its function as a helicase was determined from its structure.