DDX41

DDX41
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P6N, 5GVR, 5H1Y, 5GVS, 8C6J
Identifiers
Aliases	DDX41, ABS, MPLPF, DEAD-box helicase 41
External IDs	OMIM: 608170; MGI: 1920185; HomoloGene: 9431; GeneCards: DDX41; OMA:DDX41 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,516,961 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,684,471 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right frontal lobe; ; anterior cingulate cortex; ; sural nerve; ; mucosa of transverse colon; ; right hemisphere of cerebellum; ; stromal cell of endometrium; ; prefrontal cortex; ; nucleus accumbens; ; monocyte;
	Top expressed in
	primitive streak; ; right kidney; ; proximal tubule; ; granulocyte; ; spermatocyte; ; embryo; ; ventricular zone; ; epiblast; ; embryo; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; metal ion binding; protein binding; nucleic acid binding; hydrolase activity; ATP binding; RNA binding;
Cellular component	cytosol; catalytic step 2 spliceosome; membrane; endoplasmic reticulum; nucleus; spliceosomal complex; nucleolus; cytoplasm;
Biological process	cellular response to interferon-beta; mRNA processing; regulation of type I interferon production; defense response to virus; RNA secondary structure unwinding; RNA splicing; positive regulation of type I interferon production; positive regulation of transcription by RNA polymerase II; apoptotic process; mRNA splicing, via spliceosome; cell population proliferation; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	51428
	72935
	ENSG00000183258
	ENSMUSG00000021494
	Q9UJV9
	Q91VN6
	NM_016222; NM_001321732; NM_001321830
	NM_134059
	NP_001308661; NP_001308759; NP_057306
	NP_598820
	Wikidata
View/Edit Human	View/Edit Mouse

Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the gene is widely required during post-transcriptional gene expression. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.