DDX5

DDX5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FE2, 4A4D
Identifiers
Aliases	DDX5, G17P1, HLR1, HUMP68, p68, DEAD-box helicase 5
External IDs	OMIM: 180630; MGI: 105037; HomoloGene: 6797; GeneCards: DDX5; OMA:DDX5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	64,508,199 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,680,011 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; bone marrow cells; ; granulocyte; ; anterior pituitary; ; right adrenal cortex; ; smooth muscle tissue; ; epithelium of colon; ; gonad; ; monocyte; ; right lobe of thyroid gland;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; neural layer of retina; ; olfactory tubercle; ; granulocyte; ; habenula; ; median eminence; ; pineal gland; ; arcuate nucleus; ; lateral septal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; helicase activity; calcium-dependent protein binding; calmodulin binding; protein binding; androgen receptor binding; nucleic acid binding; enzyme binding; pre-mRNA binding; hydrolase activity; ATP binding; RNA helicase activity; RNA binding; mRNA 3'-UTR binding; ribonucleoprotein complex binding; promoter-specific chromatin binding; MH2 domain binding; SMAD binding; R-SMAD binding; primary miRNA binding; transcription coregulator activity;
Cellular component	catalytic step 2 spliceosome; membrane; nucleolus; spliceosomal complex; extracellular exosome; nucleus; extracellular matrix; nucleoplasm; SMAD protein complex; cytoplasm; ribonucleoprotein complex;
Biological process	regulation of skeletal muscle cell differentiation; regulation of transcription, DNA-templated; rhythmic process; regulation of viral genome replication; mRNA processing; mRNA transcription; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; cell growth; regulation of osteoblast differentiation; RNA secondary structure unwinding; intrinsic apoptotic signaling pathway by p53 class mediator; RNA splicing; regulation of androgen receptor signaling pathway; positive regulation of DNA damage response, signal transduction by p53 class mediator; mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process; alternative mRNA splicing, via spliceosome; regulation of transcription by RNA polymerase II; intracellular estrogen receptor signaling pathway; androgen receptor signaling pathway; epithelial to mesenchymal transition; myoblast differentiation; pri-miRNA transcription by RNA polymerase II; BMP signaling pathway; regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of production of miRNAs involved in gene silencing by miRNA;
	Sources:Amigo / QuickGO
Orthologs
	1655
	13207
	ENSG00000108654
	ENSMUSG00000020719
	P17844
	Q61656
	NM_004396; NM_001320595; NM_001320596; NM_001320597
	NM_007840; NM_001355676; NM_001355677
	NP_001307524; NP_001307525; NP_001307526; NP_004387
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.