DEFA3

DEFA3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1DFN, 1ZMH, 1ZMI, 1ZMK, 2PM4, 2PM5
Identifiers
Aliases	DEFA3, DEF3, HNP-3, HNP3, HP-3, HP3, defensin alpha 3
External IDs	OMIM: 604522; HomoloGene: 128756; GeneCards: DEFA3; OMA:DEFA3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	7,018,297 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; monocyte; ; granulocyte; ; right lung; ; blood; ; spleen; ; upper lobe of left lung; ; placenta; ; right lobe of liver;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; molecular function;
Cellular component	extracellular region; extracellular exosome; azurophil granule lumen; Golgi lumen; extracellular space;
Biological process	defense response to fungus; intracellular estrogen receptor signaling pathway; defense response to bacterium; innate immune response in mucosa; defense response; defense response to virus; antimicrobial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; antibacterial humoral response; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; membrane disruption in other organism; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	1668
	n/a
	ENSG00000239839; ENSG00000284835
	n/a
	P59666
	n/a
	NM_005217
	n/a
	NP_005208
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Defensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene. Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides.