DEFA5

DEFA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZMP, 2LXZ, 2MIT, 3I5W, 4E82, 4E83, 4E86, 4RBW, 4RBX, 5CUM, 5CUJ, 5CUI
Identifiers
Aliases	DEFA5, DEF5, HD-5, defensin alpha 5, alpha defensin 5
External IDs	OMIM: 600472; MGI: 3711900; HomoloGene: 128604; GeneCards: DEFA5; OMA:DEFA5 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	7,056,739 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	21,556,012 bp
RNA expression pattern
	Top expressed in
	duodenum; ; gonad; ; testicle; ; appendix; ; gastric mucosa; ; right lung; ; transverse colon; ; lymph node; ; rectum; ; blood;
	Top expressed in
	ileum; ; jejunum; ; duodenum; ; embryo; ; colon; ; pancreas; ; thymus; ; esophagus; ; liver; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity;
Cellular component	Golgi lumen; secretory granule lumen; transport vesicle; cytoplasmic vesicle; extracellular region; extracellular space;
Biological process	defense response; defense response to bacterium; defense response to fungus; antimicrobial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response; positive regulation of membrane permeability; killing of cells of other organism; innate immune response in mucosa; antibacterial humoral response; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; membrane disruption in other organism; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	1670
	100041688
	ENSG00000164816; ENSG00000285251
	ENSMUSG00000061845
	Q01523
	E9QLQ1
	NM_021010
	NM_001177481
	NP_066290
	NP_001170952
	Wikidata
View/Edit Human	View/Edit Mouse

Defensin, alpha 5 (DEFA5) also known as human alpha defensin 5 (HD5) is a protein that in humans is encoded by the DEFA5 gene. DEFA5 is expressed in the Paneth cells of the ileum.

Defensins are a family of microbicidal and cytotoxic peptides (antimicrobial peptides; AMP) that are involved in host defense, and help to maintain homeostasis of intestinal microbiota. DEFA5 is the main AMP that controls the enteric microbiota composition by selective killing of bacterial pathogens while preserving commensals.