DEFA6

DEFA6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZMQ, 3QTE
Identifiers
Aliases	DEFA6, DEF6, HD-6, defensin alpha 6
External IDs	OMIM: 600471; MGI: 3711900; HomoloGene: 130499; GeneCards: DEFA6; OMA:DEFA6 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	6,926,076 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	21,556,012 bp
RNA expression pattern
	Top expressed in
	duodenum; ; rectum; ; mucosa of transverse colon; ; appendix; ; lymph node; ; body of pancreas; ; skin of abdomen; ; bone marrow; ; right lung; ; gastric mucosa;
	Top expressed in
	ileum; ; jejunum; ; duodenum; ; embryo; ; colon; ; pancreas; ; thymus; ; esophagus; ; liver; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein homodimerization activity;
Cellular component	Golgi lumen; extracellular region; extracellular space;
Biological process	defense response; defense response to bacterium; defense response to fungus; antimicrobial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; innate immune response in mucosa; antibacterial humoral response; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; membrane disruption in other organism; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	1671
	100041688
	ENSG00000164822; ENSG00000285136
	ENSMUSG00000061845
	Q01524
	E9QLQ1
	NM_001926
	NM_001177481
	NP_001917
	NP_001170952
	Wikidata
View/Edit Human	View/Edit Mouse

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene. DEFA6 is expressed in the Paneth cells of the ileum.