Beta defensin 1

DEFB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E4S, 1IJU, 1IJV, 1KJ5, 2NLB, 2NLC, 2NLD, 2NLE, 2NLF, 2NLG, 2NLH, 2NLP, 2NLQ, 2NLS, 2PLZ
Identifiers
Aliases	DEFB1, BD1, DEFB-1, DEFB101, HBD1, defensin beta 1
External IDs	OMIM: 602056; MGI: 1096878; HomoloGene: 88476; GeneCards: DEFB1; OMA:DEFB1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	6,877,936 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	22,285,201 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; salivary gland; ; skin of abdomen; ; minor salivary glands; ; human kidney; ; skin of leg; ; islet of Langerhans; ; mucosa of esophagus; ; olfactory zone of nasal mucosa; ; right lobe of liver;
	Top expressed in
	conjunctival fornix; ; right kidney; ; human kidney; ; islet of Langerhans; ; lip; ; cornea; ; esophagus; ; skin of external ear; ; corneal stroma; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	CCR6 chemokine receptor binding; protein binding; identical protein binding;
Cellular component	Golgi lumen; extracellular region; extracellular exosome; sperm midpiece; extracellular space; extrinsic component of membrane; microvesicle; membrane;
Biological process	chemotaxis; G protein-coupled receptor signaling pathway; defense response; innate immune response in mucosa; acute inflammatory response; response to bacterium; immune response; response to testosterone; positive regulation of flagellated sperm motility involved in capacitation; defense response to bacterium; calcium-mediated signaling using intracellular calcium source; cAMP-mediated signaling; defense response to Gram-negative bacterium; antimicrobial humoral response; innate immune response; antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium;
	Sources:Amigo / QuickGO
Orthologs
	1672
	13214
	ENSG00000164825; ENSG00000284881
	ENSMUSG00000044748
	P60022
	P56386
	NM_005218
	NM_007843
	NP_005209
	NP_031869
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-defensin 1 is a protein that in humans is encoded by the DEFB1 gene.

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member defensin, alpha 1, and has been implicated in the pathogenesis of cystic fibrosis. Single-nucleotide polymorphisms in the DEFB1 gene were associated with plasma kynurenine concentrations in major depressive disorder patients in a genome-wide association study.