Microprocessor complex subunit DGCR8

DGCR8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X47, 2YT4, 3LE4, 5B16
Identifiers
Aliases	DGCR8, C22orf12, DGCRK6, Gy1, pasha, Pasha, DGCR8 microprocessor complex subunit, microprocessor complex subunit
External IDs	OMIM: 609030; MGI: 2151114; HomoloGene: 11223; GeneCards: DGCR8; OMA:DGCR8 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	20,111,877 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; sural nerve; ; right testis; ; left testis; ; body of uterus; ; right ovary; ; right lobe of thyroid gland; ; body of pancreas; ; left ovary; ; apex of heart;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	primary miRNA binding; ribonuclease III activity; double-stranded RNA binding; protein binding; heme binding; protein homodimerization activity; metal ion binding; RNA binding; identical protein binding;
Cellular component	cytoplasm; microprocessor complex; nucleolus; nucleus; nucleoplasm; postsynaptic density;
Biological process	regulation of stem cell proliferation; primary miRNA processing; RNA phosphodiester bond hydrolysis, endonucleolytic; RNA phosphodiester bond hydrolysis; miRNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	54487
	94223
	ENSG00000128191
	ENSMUSG00000022718
	Q8WYQ5
	Q9EQM6
	NM_001190326; NM_022720
	NM_033324
	NP_001177255; NP_073557
	NP_201581
	Wikidata
View/Edit Human	View/Edit Mouse

The microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) is a protein that in humans is encoded by the DGCR8 gene. In other animals, particularly the common model organisms Drosophila melanogaster and Caenorhabditis elegans, the protein is known as Pasha (partner of Drosha). It is a required component of the RNA interference pathway.