DGKA

DGKA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TUZ
Identifiers
Aliases	DGKA, DAGK, DAGK1, DGK-alpha, diacylglycerol kinase alpha
External IDs	OMIM: 125855; MGI: 102952; HomoloGene: 1028; GeneCards: DGKA; OMA:DGKA - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	55,954,027 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,580,724 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; granulocyte; ; spleen; ; lymph node; ; mucosa of transverse colon; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; tonsil; ; rectum;
	Top expressed in
	thymus; ; lymph node; ; corneal stroma; ; mesenteric lymph nodes; ; blood; ; spleen; ; spermatid; ; granulocyte; ; colon; ; left colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; calcium ion binding; phospholipid binding; ATP binding; metal ion binding; kinase activity; diacylglycerol kinase activity; NAD+ kinase activity;
Cellular component	cytosol; plasma membrane; membrane; intracellular anatomical structure;
Biological process	platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway; intracellular signal transduction; phosphorylation; glycerolipid metabolic process; phosphatidic acid biosynthetic process; diacylglycerol metabolic process; lipid phosphorylation; metabolism; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	1606
	13139
	ENSG00000065357
	ENSMUSG00000025357
	P23743
	O88673
NM_001345; NM_201444; NM_201445; NM_201554; NM_001351033;
	NM_001351034; NM_001351035; NM_001351036; NM_001351037; NM_001351038; NM_001351039; NM_001351040
	NM_016811; NM_001358745; NM_001358746; NM_001372366; NM_001374028
NP_001336; NP_958852; NP_958853; NP_963848; NP_001337962;
	NP_001337963; NP_001337964; NP_001337965; NP_001337966; NP_001337967; NP_001337968; NP_001337969
	NP_058091; NP_001345674; NP_001345675; NP_001359295; NP_001360957
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.