DGKD

DGKD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1R79, 3BQ7
Identifiers
Aliases	DGKD, DGKdelta, dgkd-2, diacylglycerol kinase delta, DGK-delta
External IDs	OMIM: 601826; MGI: 2138334; HomoloGene: 100054; GeneCards: DGKD; OMA:DGKD - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,472,104 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,872,902 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; granulocyte; ; gastrocnemius muscle; ; bone marrow; ; skeletal muscle tissue; ; blood; ; fundus; ; bone marrow cells;
	Top expressed in
	spermatocyte; ; thymus; ; spermatid; ; granulocyte; ; brown adipose tissue; ; neural layer of retina; ; subcutaneous adipose tissue; ; mesenteric lymph nodes; ; Cerebellum; ; lobe of cerebellum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; diacylglycerol kinase activity; metal ion binding; kinase activity; protein binding; diacylglycerol binding; ATP binding; NAD+ kinase activity; identical protein binding; protein homodimerization activity; protein heterodimerization activity;
Cellular component	cytoplasm; membrane; plasma membrane; nucleus; cytosol; cytoplasmic vesicle;
Biological process	intracellular signal transduction; endocytosis; epidermal growth factor receptor signaling pathway; phosphorylation; response to organic substance; platelet activation; multicellular organism development; cell growth; protein kinase C-activating G protein-coupled receptor signaling pathway; diacylglycerol metabolic process; protein transport; second-messenger-mediated signaling; protein homooligomerization; lipid phosphorylation; metabolism; signal transduction; glycerolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8527
	227333
	ENSG00000077044; ENSG00000280873
	ENSMUSG00000070738
	Q16760
	E9PUQ8
	NM_003648; NM_152879; NM_001377259
	NM_177646
	NP_003639; NP_690618; NP_001364188
	NP_808314
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.