DGKQ

DGKQ
Identifiers
Aliases	DGKQ, DAGK, DAGK4, DAGK7, diacylglycerol kinase theta
External IDs	OMIM: 601207; MGI: 102918; HomoloGene: 20352; GeneCards: DGKQ; OMA:DGKQ - orthologs
EC number	2.7.1.107
Gene location (Human)
Chr.	Chromosome 4 (human)
End	986,895 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	108,817,538 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; pancreatic ductal cell; ; granulocyte; ; jejunal mucosa; ; mucosa of transverse colon; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; duodenum; ; mucosa of sigmoid colon; ; thymus;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; right kidney; ; lip; ; genital tubercle; ; neural layer of retina; ; jejunum; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; phospholipase binding; metal ion binding; kinase activity; kinase binding; protein binding; ATP binding; diacylglycerol kinase activity; transmembrane receptor protein tyrosine kinase activator activity; NAD+ kinase activity;
Cellular component	cytoplasm; cytosol; nuclear speck; membrane; plasma membrane; cytoskeleton; nucleus; endosome; vesicle membrane; nuclear matrix; presynapse; postsynapse; glutamatergic synapse;
Biological process	G protein-coupled receptor signaling pathway; thrombin-activated receptor signaling pathway; response to ATP; intracellular signal transduction; phosphorylation; regulation of transcription by RNA polymerase II; protein kinase C signaling; platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway; signal transduction; glycerolipid metabolic process; diacylglycerol metabolic process; lipid phosphorylation; regulation of gluconeogenesis; phosphatidic acid biosynthetic process; activation of transmembrane receptor protein tyrosine kinase activity; regulation of G protein-coupled receptor signaling pathway; positive regulation of gene expression; negative regulation of gene expression; negative regulation of peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; cAMP-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; response to cAMP; regulation of cholesterol metabolic process; regulation of TORC1 signaling; regulation of cortisol biosynthetic process; regulation of progesterone biosynthetic process; metabolism; regulation of synaptic vesicle endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1609
	110524
	ENSG00000145214
	ENSMUSG00000004815
	P52824
	Q6P5E8
	NM_001347
	NM_199011; NM_001357029
	NP_001338
	NP_950176; NP_001343958
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.