DGKZ

DGKZ
Identifiers
Aliases	DGKZ, DAGK5, DAGK6, DGK-ZETA, hDGKzeta, diacylglycerol kinase zeta
External IDs	OMIM: 601441; MGI: 1278339; HomoloGene: 37831; GeneCards: DGKZ; OMA:DGKZ - orthologs
EC number	2.7.1.107
Gene location (Human)
Chr.	Chromosome 11 (human)
End	46,380,554 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,806,209 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; granulocyte; ; Brodmann area 9; ; apex of heart; ; gastrocnemius muscle; ; right hemisphere of cerebellum; ; muscle of thigh; ; anterior pituitary;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; primary motor cortex; ; internal carotid artery; ; cingulate gyrus; ; prefrontal cortex; ; Paneth cell; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; temporal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; lipid kinase activity; metal ion binding; protein C-terminus binding; protein binding; ATP binding; kinase activity; diacylglycerol kinase activity; NAD+ kinase activity;
Cellular component	membrane; plasma membrane; nucleus; lamellipodium; cytoplasm; nuclear speck; postsynaptic density; glutamatergic synapse; cell projection;
Biological process	intracellular signal transduction; platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; cell migration; negative regulation of mitotic cell cycle; glycerolipid metabolic process; phosphorylation; diacylglycerol metabolic process; lipid phosphorylation; metabolism; signal transduction; phosphatidic acid biosynthetic process; positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8525
	104418
	ENSG00000149091
	ENSMUSG00000040479
	Q13574
	Q80UP3
NM_001105540; NM_001199266; NM_001199267; NM_001199268; NM_003646;
	NM_201532; NM_201533
	NM_001166597; NM_138306
NP_001099010; NP_001186195; NP_001186196; NP_001186197; NP_003637;
	NP_963290; NP_963291
	NP_001160069; NP_612179
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.