Desert hedgehog (protein)

Search for
Structures	Swiss-model
Domains	InterPro

desert hedgehog
desert hedgehog
Identifiers
Symbol	DHH
Alt. symbols	HHG-3, MGC35145
NCBI gene	50846
HGNC	2865
OMIM	605423
RefSeq	NM_021044
UniProt	O43323
Other data
Locus	Chr. 12 q13.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

DHH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WFQ, 2WFR, 2WG3, 3N1G, 3N1Q
Identifiers
Aliases	DHH, GDXYM, HHG-3, SRXY7, C78960, desert hedgehog, desert hedgehog signaling molecule, GDMN
External IDs	OMIM: 605423; MGI: 94891; HomoloGene: 22431; GeneCards: DHH; OMA:DHH - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,094,801 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	98,796,421 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; right testis; ; left testis; ; sural nerve; ; smooth muscle tissue; ; spinal ganglia; ; left coronary artery; ; appendix; ; right coronary artery; ; muscle of thigh;
	Top expressed in
	sciatic nerve; ; epithelium of seminiferous tubule of testis; ; Sertoli cell; ; external carotid artery; ; Gonadal ridge; ; lumbar spinal ganglion; ; internal carotid artery; ; utricle; ; pulmonary artery; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; zinc ion binding; metal ion binding; patched binding; peptidase activity; protein binding; hydrolase activity;
Cellular component	membrane; plasma membrane; extracellular region; extracellular space;
Biological process	response to estradiol; Leydig cell differentiation; cell-cell signaling; regulation of steroid biosynthetic process; male sex determination; proteolysis; response to estrogen; multicellular organism development; spermatid development; myelination; osteoblast differentiation; smoothened signaling pathway; cell fate specification; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	50846
	13363
	ENSG00000139549
	ENSMUSG00000023000
	O43323
	Q61488
	NM_021044
	NM_007857
	NP_066382
	NP_031883
	Wikidata
View/Edit Human	View/Edit Mouse

Desert hedgehog, also Desert hedgehog homolog or DHh, is a protein encoded by the DHH gene, and is a member of the hedgehog signaling pathway. The human homolog (DHH) is on chromosome band 12q13.1. The protein encoded by this gene is involved in cell signaling. The several mammalian variants of the Drosophila hedgehog gene (which was the first named) have been named after the various species of hedgehog; the desert hedgehog is honored by this one. The gene is not specific to desert hedgehogs. The Desert Hedgehog gene has been identified in both humans and mouse models.