Dehydrogenase/reductase (SDR family) X-linked also known as DHRSX is an enzyme which in humans is encoded by the pseudoautosomal DHRSX gene. DHRSX is a member of the short-chain dehydrogenase family of oxidoreductase enzymes.
DHRSX is required for two steps in the biosynthesis of dolichol: i) the NAD+-dependent conversion of polyprenol to its aldehyde analogue, polyprenal; ii) the NADPH-dependent reduction of dolichal to dolichol. Dolichol is a long polyisoprenoid lipid required as the carrier of mono- and oligosaccharides in the processes of N-glycosylation, C-/O-mannosylation and the formation of glycosylphosphatidylinositol (GPI) anchors.
