DHX36

DHX36
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N16, 2N21
Identifiers
Aliases	DHX36, DDX36, G4R1, MLEL1, RHAU, DEAH-box helicase 36
External IDs	OMIM: 612767; MGI: 1919412; HomoloGene: 6356; GeneCards: DHX36; OMA:DHX36 - orthologs
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	62,507,004 bp
RNA expression pattern
	Top expressed in
	sperm; ; lower lobe of lung; ; pancreatic ductal cell; ; caput epididymis; ; trigeminal ganglion; ; Pons; ; external globus pallidus; ; corpus epididymis; ; superficial temporal artery; ; spinal ganglia;
	Top expressed in
	ventromedial nucleus; ; lateral septal nucleus; ; Rostral migratory stream; ; mammillary body; ; lateral hypothalamus; ; lateral geniculate nucleus; ; maxillary prominence; ; anterior amygdaloid area; ; human fetus; ; cerebellar vermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; DNA binding; ATP-dependent activity, acting on DNA; helicase activity; G-quadruplex RNA binding; histone deacetylase binding; G-quadruplex DNA binding; protein binding; nucleic acid binding; double-stranded RNA binding; hydrolase activity; ATP binding; telomerase RNA binding; RNA binding; single-stranded DNA binding; magnesium ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; mRNA 3'-UTR binding; DNA helicase activity; 3'-5' RNA helicase activity; mRNA 3'-UTR AU-rich region binding; metal ion binding; mRNA 5'-UTR binding; pre-miRNA binding;
Cellular component	chromosome; telomere; extracellular exosome; cytosol; nucleus; cytoplasm; mitochondrion; cytoplasmic stress granule; nuclear speck; axon; dendrite; cell projection; perikaryon;
Biological process	RNA processing; regulation of transcription, DNA-templated; ossification; response to exogenous dsRNA; response to virus; transcription, DNA-templated; positive regulation of telomere maintenance; RNA secondary structure unwinding; positive regulation of type I interferon production; positive regulation of transcription by RNA polymerase II; telomerase RNA stabilization; immune system process; positive regulation of myeloid dendritic cell cytokine production; regulation of transcription by RNA polymerase III; regulation of translation; multicellular organism development; spermatogenesis; positive regulation of gene expression; negative regulation of translation; cell differentiation; positive regulation of mRNA 3'-end processing; DNA duplex unwinding; cellular response to heat; cellular response to UV; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of mRNA stability; G-quadruplex DNA unwinding; innate immune response; regulation of embryonic development; defense response to virus; positive regulation of cardioblast differentiation; positive regulation of transcription initiation from RNA polymerase II promoter; positive regulation of dendritic spine morphogenesis; 3'-UTR-mediated mRNA destabilization; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of hematopoietic progenitor cell differentiation; cellular response to arsenite ion; positive regulation of telomere maintenance via telomere lengthening; positive regulation of intracellular mRNA localization; positive regulation of cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologs
	170506
	72162
	n/a
	ENSMUSG00000027770
	Q9H2U1
	Q8VHK9
	NM_020865; NM_001114397
	NM_028136
	NP_001107869; NP_065916
	NP_082412
	Wikidata
View/Edit Human	View/Edit Mouse

Probable ATP-dependent RNA helicase DHX36 also known as DEAH box protein 36 (DHX36) or MLE-like protein 1 (MLEL1) or G4 resolvase 1 (G4R1) or RNA helicase associated with AU-rich elements (RHAU) is an enzyme that in humans is encoded by the DHX36 gene.