LGP2

DHX58
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RQA, 2W4R, 3EQT
Identifiers
Aliases	DHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
External IDs	OMIM: 608588; MGI: 1931560; HomoloGene: 69371; GeneCards: DHX58; OMA:DHX58 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,112,714 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,595,097 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right lobe of liver; ; right uterine tube; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; apex of heart; ; monocyte; ; left ovary; ; tibial nerve;
	Top expressed in
	granulocyte; ; spermatocyte; ; spermatid; ; seminiferous tubule; ; adrenal gland; ; mucous cell of stomach; ; lumbar spinal ganglion; ; stroma of bone marrow; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; zinc ion binding; metal ion binding; protein binding; single-stranded RNA binding; RNA binding; double-stranded RNA binding; hydrolase activity; ATP binding;
Cellular component	cytoplasm;
Biological process	negative regulation of MDA-5 signaling pathway; regulation of innate immune response; immune system process; response to virus; positive regulation of RIG-I signaling pathway; defense response to virus; negative regulation of innate immune response; negative regulation of type I interferon production; innate immune response; viral process; positive regulation of MDA-5 signaling pathway; positive regulation of type I interferon production; negative regulation of RIG-I signaling pathway; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	79132
	80861
	ENSG00000108771
	ENSMUSG00000017830
	Q96C10
	Q99J87
	NM_024119
	NM_030150
	NP_077024
	NP_084426
	Wikidata
View/Edit Human	View/Edit Mouse

Probable ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the DHX58 gene. The protein encoded by the gene DHX58 is known as LGP2 (Laboratory of Genetics and Physiology 2).