DHX8

DHX8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EQS, 3I4U
Identifiers
Aliases	DHX8, DDX8, HRH1, PRP22, PRPF22, DEAH-box helicase 8, Dhr2
External IDs	OMIM: 600396; MGI: 1306823; HomoloGene: 3628; GeneCards: DHX8; OMA:DHX8 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	43,610,338 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,658,184 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; mucosa of transverse colon; ; skin of abdomen; ; ganglionic eminence; ; ventricular zone; ; ectocervix; ; granulocyte; ; stromal cell of endometrium; ; monocyte; ; anterior pituitary;
	Top expressed in
	interventricular septum; ; epiblast; ; tail of embryo; ; spermatid; ; granulocyte; ; seminiferous tubule; ; ventricular zone; ; mandibular prominence; ; zygote; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; helicase activity; hydrolase activity; identical protein binding; nucleic acid binding; RNA binding; 3'-5' RNA helicase activity;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; nucleus; nucleoplasm; cytoplasm; nuclear body; U2-type catalytic step 2 spliceosome;
Biological process	mRNA processing; RNA processing; RNA splicing; mRNA splicing, via spliceosome; spliceosomal complex disassembly;
	Sources:Amigo / QuickGO
Orthologs
	1659
	217207
	ENSG00000067596
	ENSMUSG00000034931
	Q14562; Q05CV4
	A2A4P0
NM_001302623; NM_004941; NM_001322216; NM_001322217; NM_001322218;
	NM_001322219; NM_001322220; NM_001322221
	NM_144831
NP_001289552; NP_001309145; NP_001309146; NP_001309147; NP_001309148;
	NP_001309149; NP_001309150; NP_004932; NP_001289552.1; NP_004932.1
	NP_659080
	Wikidata
View/Edit Human	View/Edit Mouse

DEAH-box helicase 8, is a protein that in humans is encoded by the DHX8 gene. This protein is member of the DEAH box polypeptide family. The main characteristic of this group is their conserved motif DEAH (Asp- Glu- Ala- His). A wide range of RNA helicases belongs to this family. Specifically, DHX8 acts as an ATP-dependent RNA helicase involved in splicing and the regulation of the releasing of spliced mRNAs from spliceosomes out of the nucleus. Published studies have shown the consequences of DHX8 mutations, some of them are critical for biological processes such as hematopoiesis and are related to some diseases.