RNA Helicase A

DHX9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LLM, 3VYX, 3VYY
Identifiers
Aliases	DHX9, DDX9, LKP, NDH2, NDHII, RHA, RNA Helicase A, DEAH-box helicase 9, DExH-box helicase 9
External IDs	OMIM: 603115; MGI: 108177; HomoloGene: 1039; GeneCards: DHX9; OMA:DHX9 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	182,887,982 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	153,363,406 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; sperm; ; Achilles tendon; ; right ovary; ; left ovary; ; right testis; ; canal of the cervix; ; body of uterus; ; left testis;
	Top expressed in
	tail of embryo; ; primitive streak; ; abdominal wall; ; otic placode; ; mandibular prominence; ; maxillary prominence; ; Gonadal ridge; ; vas deferens; ; saccule; ; otic vesicle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA helicase activity; nucleotide binding; helicase activity; protein binding; nucleic acid binding; hydrolase activity; RNA binding; DNA binding; single-stranded DNA binding; double-stranded RNA binding; single-stranded RNA binding; nucleoside-triphosphatase activity; chromatin DNA binding; 3'-5' DNA/RNA helicase activity; 3'-5' RNA helicase activity; triplex DNA binding; nucleoside-triphosphate diphosphatase activity; importin-alpha family protein binding; single-stranded 3'-5' DNA helicase activity; siRNA binding; mRNA binding; RNA stem-loop binding; polysome binding; promoter-specific chromatin binding; RNA polymerase II complex binding; regulatory region RNA binding; transcription coregulator activity; transcription coactivator activity; DNA replication origin binding; double-stranded DNA binding; DNA helicase activity; ATP binding; ATPase activity; RNA polymerase binding; 3'-5' DNA helicase activity; RISC complex binding; sequence-specific mRNA binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	CRD-mediated mRNA stability complex; cytosol; centrosome; membrane; cytoplasmic ribonucleoprotein granule; nucleus; nucleolus; perichromatin fibrils; cytoplasm; nuclear stress granule; nuclear body; polysomal ribosome; polysome; actin cytoskeleton; RISC-loading complex; nucleoplasm; microtubule organizing center; cytoskeleton; protein-containing complex; ribonucleoprotein complex;
Biological process	CRD-mediated mRNA stabilization; mRNA splicing, via spliceosome; RNA processing; rhythmic process; protein localization to cytoplasmic stress granule; osteoblast differentiation; positive regulation of type I interferon production; RNA secondary structure unwinding; positive regulation of DNA repair; positive regulation of transcription by RNA polymerase II; positive regulation of response to cytokine stimulus; cellular response to exogenous dsRNA; alternative mRNA splicing, via spliceosome; DNA-templated viral transcription; positive regulation of viral transcription; positive regulation of viral translation; positive regulation of cytoplasmic translation; regulation of transcription by RNA polymerase II; DNA duplex unwinding; positive regulation of DNA replication; positive regulation of fibroblast proliferation; regulation of mRNA processing; positive regulation of NF-kappaB transcription factor activity; cellular response to tumor necrosis factor; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; regulation of cytoplasmic translation; positive regulation of interleukin-18 production; G-quadruplex DNA unwinding; positive regulation of innate immune response; positive regulation of RNA export from nucleus; regulation of defense response to virus by host; positive regulation of inflammatory response; pyroptosis; small RNA loading onto RISC; positive regulation of polysome binding; positive regulation of gene silencing by miRNA; immune system process; DNA replication; transcription, DNA-templated; DNA-templated transcription, termination; regulation of transcription, DNA-templated; mRNA processing; regulation of translation; transport; inflammatory response; RNA splicing; gene silencing; innate immune response; mRNA transport;
	Sources:Amigo / QuickGO
Orthologs
	1660
	13211
	ENSG00000135829
	ENSMUSG00000042699
	Q08211
	O70133
	NM_001357; NM_030588
	NM_007842
	NP_001348
	NP_031868; NP_001392438
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent RNA helicase A (RHA; also known as DHX9, LKP, and NDHI) is an enzyme that in humans is encoded by the DHX9 gene.