DIO2

DIO2
Identifiers
Aliases	DIO2, 5DII, D2, DIOII, SelY, TXDI2, deiodinase, iodothyronine, type II, iodothyronine deiodinase 2, SELENOY
External IDs	OMIM: 601413; MGI: 1338833; HomoloGene: 621; GeneCards: DIO2; OMA:DIO2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	80,387,757 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	90,705,212 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; tendon of biceps brachii; ; body of tongue; ; superior surface of tongue; ; oral cavity; ; thyroid gland; ; right lobe of thyroid gland; ; nipple; ; human penis; ; left lobe of thyroid gland;
	Top expressed in
	median eminence; ; cervix; ; ascending aorta; ; ligament; ; Region I of hippocampus proper; ; arcuate nucleus; ; lumbar subsegment of spinal cord; ; aortic valve; ; spiral ligament; ; perirhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; selenium binding; thyroxine 5'-deiodinase activity; ubiquitin protein ligase binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	thyroid hormone metabolic process; thyroid hormone generation; selenocysteine incorporation; hormone biosynthetic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1734
	13371
	ENSG00000211448
	ENSMUSG00000007682
	Q92813
	Q9Z1Y9
NM_013989; NM_000793; NM_001007023; NM_001242503; NM_001324462;
	NM_001366496
	NM_010050
	NP_000784; NP_001311391; NP_054644; NP_001353425
	NP_034180
	Wikidata
View/Edit Human	View/Edit Mouse

Type II iodothyronine deiodinase (iodothyronine 5'-deiodinase, iodothyronine 5'-monodeiodinase) is an enzyme that in humans is encoded by the DIO2 gene.