DIS3

DIS3
Identifiers
Aliases	DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
External IDs	OMIM: 607533; MGI: 1919912; HomoloGene: 6910; GeneCards: DIS3; OMA:DIS3 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	72,782,096 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	99,337,206 bp
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; ventricular zone; ; testicle; ; stromal cell of endometrium; ; ganglionic eminence; ; rectum; ; islet of Langerhans; ; popliteal artery; ; tibial arteries;
	Top expressed in
	primitive streak; ; spermatid; ; epiblast; ; tail of embryo; ; seminiferous tubule; ; somite; ; abdominal wall; ; genital tubercle; ; endothelial cell of lymphatic vessel; ; Paneth cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nuclease activity; hydrolase activity; guanyl-nucleotide exchange factor activity; exonuclease activity; RNA binding; protein binding; endonuclease activity; 3'-5'-exoribonuclease activity; ribonuclease activity;
Cellular component	nucleolus; nucleoplasm; cytoplasm; exosome (RNase complex); nuclear exosome (RNase complex); membrane; nucleus; cytosol; cytoplasmic exosome (RNase complex);
Biological process	exonucleolytic catabolism of deadenylated mRNA; regulation of mRNA stability; CUT catabolic process; rRNA processing; rRNA catabolic process; nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, exonucleolytic; regulation of molecular function; RNA catabolic process; RNA phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	22894
	72662
	ENSG00000083520
	ENSMUSG00000033166
	Q9Y2L1
	Q9CSH3
	NM_001128226; NM_014953; NM_001322348; NM_001322349
	NM_028315; NM_001360050; NM_001360051
	NP_001121698; NP_001309277; NP_001309278; NP_055768
	NP_082591; NP_001346979; NP_001346980
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.