DKK3

DKK3
Identifiers
Aliases	DKK3, REIC, RIG, dickkopf WNT signaling pathway inhibitor 3, CRRL
External IDs	OMIM: 605416; MGI: 1354952; HomoloGene: 8303; GeneCards: DKK3; OMA:DKK3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	12,009,769 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	111,758,264 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; lateral nuclear group of thalamus; ; external globus pallidus; ; right auricle of heart; ; tendon of biceps brachii; ; entorhinal cortex; ; pars compacta; ; vena cava;
	Top expressed in
	epithelium of lens; ; ciliary body; ; iris; ; neural layer of retina; ; aortic valve; ; calvaria; ; ascending aorta; ; utricle; ; dentate gyrus of hippocampal formation granule cell; ; primary motor cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	co-receptor binding; receptor antagonist activity;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of anti-Mullerian hormone signaling pathway; multicellular organism development; negative regulation of cortisol biosynthetic process; negative regulation of Wnt signaling pathway; anatomical structure morphogenesis; negative regulation of transcription, DNA-templated; Wnt signaling pathway; adrenal gland development; negative regulation of canonical Wnt signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of aldosterone biosynthetic process; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	27122
	50781
	ENSG00000050165
	ENSMUSG00000030772
	Q9UBP4
	Q9QUN9
	NM_001018057; NM_013253; NM_015881; NM_001330220
	NM_015814; NM_001360257; NM_001360260; NM_001360261
	NP_001018067; NP_001317149; NP_037385; NP_056965
	NP_056629; NP_001347186; NP_001347189; NP_001347190
	Wikidata
View/Edit Human	View/Edit Mouse

Dickkopf-related protein 3 is a protein in the Dickkopf family that in humans is encoded by the DKK3 gene.

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.