DLC1

DLC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DKY, 2GYT, 2KAP, 2LOZ, 3KUQ, 5FZT
Identifiers
Aliases	DLC1, ARHGAP7, HP, STARD12, p122-RhoGAP, DLC1 Rho GTPase activating protein
External IDs	OMIM: 604258; MGI: 1354949; HomoloGene: 4442; GeneCards: DLC1; OMA:DLC1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	13,604,610 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	37,420,297 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; sural nerve; ; Achilles tendon; ; pericardium; ; upper lobe of lung; ; upper lobe of left lung; ; visceral pleura; ; synovial joint; ; epithelium of colon; ; right lung;
	Top expressed in
	left lung lobe; ; aortic valve; ; right lung lobe; ; ascending aorta; ; brown adipose tissue; ; interventricular septum; ; external carotid artery; ; pineal gland; ; sciatic nerve; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SH2 domain binding; protein binding; lipid binding; GTPase activator activity;
Cellular component	cytosol; membrane; ruffle membrane; cell junction; cortical actin cytoskeleton; caveola; nucleus; cytoplasm; focal adhesion;
Biological process	positive regulation of execution phase of apoptosis; regulation of actin cytoskeleton organization; positive regulation of protein dephosphorylation; negative regulation of Rho protein signal transduction; heart morphogenesis; focal adhesion assembly; neural tube closure; regulation of cell shape; hindbrain morphogenesis; forebrain development; negative regulation of stress fiber assembly; regulation of Rho protein signal transduction; activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of small GTPase mediated signal transduction; negative regulation of focal adhesion assembly; actin cytoskeleton organization; signal transduction; negative regulation of cell population proliferation; apoptotic process; negative regulation of cell migration; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	10395
	50768
	ENSG00000164741; ENSG00000288673
	ENSMUSG00000031523
	Q96QB1
	Q9R0Z9
NM_001164271; NM_001316668; NM_006094; NM_024767; NM_182643;
	NM_001348081; NM_001348082; NM_001348083; NM_001348084
	NM_001194940; NM_001194941; NM_015802; NM_178735
NP_001157743; NP_001303597; NP_006085; NP_079043; NP_872584;
	NP_001335010; NP_001335011; NP_001335012; NP_001335013
	NP_001181869; NP_001181870; NP_056617
	Wikidata
View/Edit Human	View/Edit Mouse

Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 (STARD12) is a protein which in humans is encoded by the DLC1 gene.

This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22-p21.3, a region frequently deleted in solid tumors. It is suggested that this gene is a candidate tumor suppressor gene for human liver cancer, as well as for prostate, lung, colorectal, and breast cancers.