DLGAP5

DLGAP5
Identifiers
Aliases	DLGAP5, DLG7, HURP, discs large homolog associated protein 5, DLG associated protein 5
External IDs	OMIM: 617859; MGI: 2183453; HomoloGene: 8840; GeneCards: DLGAP5; OMA:DLGAP5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	55,191,608 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,655,864 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; gonad; ; embryo; ; ganglionic eminence; ; trabecular bone; ; testicle; ; bone marrow; ; bone marrow cells; ; sperm;
	Top expressed in
	tail of embryo; ; zygote; ; genital tubercle; ; primary oocyte; ; yolk sac; ; secondary oocyte; ; ventricular zone; ; blastocyst; ; epiblast; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphoprotein phosphatase activity;
Cellular component	microtubule organizing center; nucleus; cytoskeleton; spindle; spindle pole centrosome; cytoplasm; mitochondrion; cytosol;
Biological process	positive regulation of mitotic metaphase/anaphase transition; cell cycle; mitotic chromosome movement towards spindle pole; cell population proliferation; signaling; protein dephosphorylation; positive regulation of transcription of Notch receptor target;
	Sources:Amigo / QuickGO
Orthologs
	9787
	218977
	ENSG00000126787
	ENSMUSG00000037544
	Q15398
	Q8K4R9
	NM_001146015; NM_014750
	NM_001145949; NM_144553
	NP_001139487; NP_055565
	NP_653136
	Wikidata
View/Edit Human	View/Edit Mouse

Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.

DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture. DGL7 is a part of Ran-dependent complex. Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase. Expression of DGL7 is found in cancer and stem cells.