DLL4

DLL4
Identifiers
Aliases	DLL4, hdelta2, AOS6, delta like canonical Notch ligand 4, delta4
External IDs	OMIM: 605185; MGI: 1859388; HomoloGene: 10411; GeneCards: DLL4; OMA:DLL4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	40,939,073 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,166,443 bp
RNA expression pattern
	Top expressed in
	vena cava; ; apex of heart; ; body of tongue; ; pericardium; ; upper lobe of left lung; ; subcutaneous adipose tissue; ; left ventricle; ; atrium; ; right atrium; ; cardia;
	Top expressed in
	interventricular septum; ; vasculature of trunk; ; lamina propria of small intestine; ; umbilical artery; ; dorsal aorta; ; right lung; ; endothelium of artery; ; right ventricle; ; gastrula; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; Notch binding; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	Notch signaling pathway; dorsal aorta morphogenesis; cell differentiation; negative regulation of blood vessel endothelial cell migration; response to stimulus; negative regulation of transcription by RNA polymerase II; blood vessel lumenization; cellular response to fibroblast growth factor stimulus; blood circulation; negative regulation of gene expression; nervous system development; ventricular trabecula myocardium morphogenesis; negative regulation of endothelial cell migration; regulation of neural retina development; positive regulation of neural precursor cell proliferation; negative regulation of cell migration involved in sprouting angiogenesis; cell communication; multicellular organism development; blood vessel remodeling; T cell differentiation; positive regulation of gene expression; ventral spinal cord interneuron fate commitment; angiogenesis; pericardium morphogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; branching involved in blood vessel morphogenesis; cellular response to vascular endothelial growth factor stimulus; cardiac atrium morphogenesis; cardiac ventricle morphogenesis; regulation of neurogenesis; signal transduction; visual perception; negative regulation of cell population proliferation; negative regulation of Notch signaling pathway; positive regulation of Notch signaling pathway; Notch signaling involved in heart development; aortic valve morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	54567
	54485
	ENSG00000128917
	ENSMUSG00000027314
	Q9NR61
	Q9JI71
	NM_019074
	NM_019454
	NP_061947
	NP_062327
	Wikidata
View/Edit Human	View/Edit Mouse

Delta-like 4 is a protein that in humans is encoded by the DLL4 gene.

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.