DLX5

DLX5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DJN, 4RDU
Identifiers
Aliases	DLX5, SHFM1D, AI385752, distal-less homeobox 5, SHFM1
External IDs	OMIM: 600028; MGI: 101926; HomoloGene: 3825; GeneCards: DLX5; OMA:DLX5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	97,024,950 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	6,882,085 bp
RNA expression pattern
	Top expressed in
	tibia; ; gonad; ; skin of leg; ; endometrium; ; skin of abdomen; ; testicle; ; Achilles tendon; ; placenta; ; periodontal fiber; ; ganglionic eminence;
	Top expressed in
	neural plate; ; neural groove; ; neural fold; ; molar; ; medial ganglionic eminence; ; genital tubercle; ; Apical ectodermal ridge; ; subthalamus; ; surface ectoderm; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; HMG box domain binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	cytoplasm; nucleus;
Biological process	skeletal system development; roof of mouth development; regulation of transcription, DNA-templated; epithelial cell differentiation; axonogenesis; ossification; positive regulation of epithelial cell proliferation; positive regulation of canonical Wnt signaling pathway; anatomical structure formation involved in morphogenesis; bone morphogenesis; head development; cellular response to BMP stimulus; ear development; endochondral ossification; transcription by RNA polymerase II; BMP signaling pathway; olfactory pit development; transcription, DNA-templated; nervous system development; axon guidance; positive regulation of transcription, DNA-templated; multicellular organism development; embryonic limb morphogenesis; inner ear morphogenesis; osteoblast differentiation; cell population proliferation; face morphogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of gene expression; olfactory bulb interneuron differentiation; interneuron axon guidance; regulation of transcription by RNA polymerase II; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1749
	13395
	ENSG00000105880
	ENSMUSG00000029755
	P56178
	P70396
	NM_005221
	NM_010056; NM_198854
	NP_005212
	NP_034186; NP_942151
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein DLX-5 is a protein that in humans is encoded by the distal-less homeobox 5 gene, or DLX5 gene. DLX5 is a member of the DLX gene family.