DMC1 (gene)

DMC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V5W, 2ZJB, 4HYY
Identifiers
Aliases	DMC1, DMC1H, LIM15, dJ199H16.1, DNA meiotic recombinase 1
External IDs	OMIM: 602721; MGI: 105393; HomoloGene: 5135; GeneCards: DMC1; OMA:DMC1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,570,204 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,489,310 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; gonad; ; right testis; ; left testis; ; ventricular zone; ; testicle; ; Achilles tendon; ; ganglionic eminence; ; muscle of thigh; ; tonsil;
	Top expressed in
	morula; ; seminiferous tubule; ; blastocyst; ; spermatid; ; embryo; ; secondary oocyte; ; embryo; ; granulocyte; ; primary oocyte; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; DNA strand exchange activity; single-stranded DNA binding; protein binding; four-way junction DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; ATP binding;
Cellular component	chromosome; nucleoplasm; telomere; nucleus; condensed nuclear chromosome;
Biological process	strand invasion; response to ionizing radiation; DNA recombinase assembly; female gamete generation; male meiosis I; DNA metabolic process; gamete generation; homologous chromosome pairing at meiosis; oocyte maturation; spermatogenesis; spermatid development; ovarian follicle development; cell cycle; chromosome organization involved in meiotic cell cycle; mitotic recombination; DNA repair; reciprocal meiotic recombination; meiosis;
	Sources:Amigo / QuickGO
Orthologs
	11144
	13404
	ENSG00000100206
	ENSMUSG00000022429
	Q14565
	Q61880
	NM_001278208; NM_007068; NM_001363017
	NM_001278226; NM_010059
	NP_001265137; NP_008999; NP_001349946
	NP_001265155; NP_034189
	Wikidata
View/Edit Human	View/Edit Mouse

Meiotic recombination protein DMC1/LIM15 homolog is a protein that in humans is encoded by the DMC1 gene.

Meiotic recombination protein Dmc1 is a homolog of the bacterial strand exchange protein RecA. Dmc1 plays the central role in homologous recombination in meiosis by assembling at the sites of programmed DNA double strand breaks and carrying out a search for allelic DNA sequences located on homologous chromatids. The name "Dmc" stands for "disrupted meiotic cDNA" and refers to the method used for its discovery which involved using clones from a meiosis-specific cDNA library to direct knock-out mutations of abundantly expressed meiotic genes

The Dmc1 protein is one of two homologs of RecA found in eukaryotic cells, the other being Rad51. DMC1 and RAD51 share over 50% amino acid similarity. In budding yeast, Rad51 serves as a strand exchange protein in mitosis where it is critical for the repair of DNA breaks. Rad51 is converted to an accessory factor for Dmc1 during meiosis by inhibition of its strand exchange activity. Homologs of DMC1 are well conserved and have been identified in many organisms including divergent fungi, plants and mammals including humans.