DMRT1

DMRT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YJ0
Identifiers
Aliases	DMRT1, CT154, DMT1, doublesex and mab-3 related transcription factor 1
External IDs	OMIM: 602424; MGI: 1354733; HomoloGene: 9280; GeneCards: DMRT1; OMA:DMRT1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	969,090 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	25,581,693 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; buccal mucosa cell; ; right testis; ; left testis; ; olfactory zone of nasal mucosa; ; germ cell; ; male germ cell; ; placenta; ; thyroid gland;
	Top expressed in
	Gonadal ridge; ; seminiferous tubule; ; epithelium of seminiferous tubule of testis; ; Sertoli cell; ; spermatogonium; ; spermatid; ; morula; ; morula; ; embryo; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; metal ion binding; protein heterodimerization activity; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; protein homodimerization activity; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	cell differentiation; intracellular signal transduction; male gonad development; regulation of transcription, DNA-templated; regulation of nodal signaling pathway; Sertoli cell differentiation; positive regulation of meiosis I; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; male sex determination; negative regulation of meiotic nuclear division; Sertoli cell development; oocyte development; transcription, DNA-templated; multicellular organism development; developmental process involved in reproduction; male germ cell proliferation; male sex differentiation; cell morphogenesis; spermatogenesis; positive regulation of mitotic nuclear division; positive regulation of male gonad development; germ cell migration; positive regulation of transcription by RNA polymerase II; sex differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1761
	50796
	ENSG00000137090
	ENSMUSG00000024837
	Q9Y5R6
	Q9QZ59
	NM_021951; NM_001363767
	NM_015826
	NP_068770; NP_001350696
	NP_056641
	Wikidata
View/Edit Human	View/Edit Mouse

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.