DNA2L

DNA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EAY
Identifiers
Aliases	DNA2, DNA2L, hDNA replication helicase/nuclease 2
External IDs	OMIM: 601810; MGI: 2443732; HomoloGene: 6124; GeneCards: DNA2; OMA:DNA2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	68,472,121 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,809,964 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; testicle; ; ventricular zone; ; ganglionic eminence; ; right lobe of liver; ; Epithelium of choroid plexus; ; rectum; ; trabecular bone; ; stromal cell of endometrium;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; primitive streak; ; abdominal wall; ; otic placode; ; epiblast; ; otic vesicle; ; tibiofemoral joint; ; migratory enteric neural crest cell; ; mandibular prominence; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; 4 iron, 4 sulfur cluster binding; nucleotide binding; helicase activity; iron-sulfur cluster binding; metal ion binding; 5'-flap endonuclease activity; DNA helicase activity; ATPase activity; protein binding; catalytic activity; 5'-3' DNA helicase activity; nuclease activity; endonuclease activity; site-specific endodeoxyribonuclease activity, specific for altered base; hydrolase activity; ATP binding; single-stranded DNA helicase activity; RNA binding;
Cellular component	nucleoplasm; gamma DNA polymerase complex; mitochondrial nucleoid; nucleus; mitochondrion; cytoplasm;
Biological process	mitotic telomere maintenance via semi-conservative replication; mitochondrial DNA repair; nucleic acid phosphodiester bond hydrolysis; DNA double-strand break processing; mitochondrial DNA replication; cellular response to DNA damage stimulus; DNA replication checkpoint signaling; positive regulation of DNA replication; metabolism; base-excision repair; DNA replication, removal of RNA primer; DNA replication; telomere maintenance; DNA duplex unwinding; DNA repair; G-quadruplex DNA unwinding; t-circle formation; telomere maintenance via semi-conservative replication; DNA replication, Okazaki fragment processing; replication fork reversal; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	1763
	327762
	ENSG00000138346
	ENSMUSG00000036875
	P51530
	Q6ZQJ5
	NM_001080449
	NM_177372
	NP_001073918
	NP_796346
	Wikidata
View/Edit Human	View/Edit Mouse

DNA2-like helicase is an enzyme that in humans is encoded by the DNA2 gene. Dna2, a homolog of DNA2KL present in budding yeast, possesses both helicase and nuclease activity, with which it helps catalyze early steps in homologous recombination.