DNASE1L1

DNASE1L1
Identifiers
Aliases	DNASE1L1, DNAS1L1, DNASEX, DNL1L, G4.8, XIB, deoxyribonuclease I-like 1, deoxyribonuclease 1 like 1
External IDs	OMIM: 300081; MGI: 109628; HomoloGene: 4896; GeneCards: DNASE1L1; OMA:DNASE1L1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,412,112 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,325,943 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; glutes; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; apex of heart; ; stromal cell of endometrium; ; triceps brachii muscle; ; tendon of biceps brachii;
	Top expressed in
	quadriceps femoris muscle; ; muscle of thigh; ; skeletal muscle tissue; ; bone marrow; ; zone of skin; ; esophagus; ; duodenum; ; granulocyte; ; lip; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nuclease activity; endonuclease activity; hydrolase activity; deoxyribonuclease activity; deoxyribonuclease I activity;
Cellular component	endoplasmic reticulum; extracellular region; specific granule lumen; nucleus;
Biological process	DNA metabolic process; DNA catabolic process; nucleic acid phosphodiester bond hydrolysis; neutrophil degranulation; DNA catabolic process, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	1774
	69537
	ENSG00000013563
	ENSMUSG00000019088
	P49184
	Q9D7J6
	NM_001009932; NM_001009933; NM_001009934; NM_001303620; NM_006730
	NM_001172154; NM_027109; NM_001370787
	NP_001009932; NP_001009933; NP_001009934; NP_001290549; NP_006721
	NP_001165625; NP_081385; NP_001357716
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyribonuclease-1-like 1 is an enzyme that in humans is encoded by the DNASE1L1 gene. It is also known as DNaseX due to its localisation on the X chromosome.

This gene encodes a member of the deoxyribonuclease family and the protein and DNA shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.

The DNase1L1/DNaseX gene was discovered in the early 1990s by Johannes F. Coy as a member of the Molecular Genome Analysis research project at the DKFZ (German Cancer Research Center) in Heidelberg and first published in 1996.

Just like the DNase I enzyme produced by the DNase I gene, the DNase1L1 (DNaseX) enzyme produced by the DNase1L1 (DNaseX) gene cuts double-stranded deoxyribonucleic acid (DNA) molecular chains into pieces. The cutting of DNA into 300-base pair pieces represents the final step in the execution of programmed cell death (apoptosis). Cells can then no longer perform cell division and thus cannot develop into tumor cells. DNase I and DNase1L1 (DNaseX) carry out programmed cell death (apoptosis) and thus protect the human body from the development of tumor cells. Conversely, the absence of DNase enzyme activity leads to the increased formation of tumor cells, as the execution of apoptosis is prevented.