Deoxyribonuclease gamma

DNASE1L3
Identifiers
Aliases	DNASE1L3, DHP2, DNAS1L3, LSD, SLEB16, deoxyribonuclease I like 3, deoxyribonuclease 1 like 3
External IDs	OMIM: 602244; MGI: 1314633; HomoloGene: 3630; GeneCards: DNASE1L3; OMA:DNASE1L3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	58,214,697 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	14,505,240 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; spleen; ; gingival epithelium; ; trabecular bone; ; liver; ; mucosa of sigmoid colon; ; right lobe of liver; ; left adrenal cortex; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	lumbar spinal ganglion; ; mesenteric lymph nodes; ; left lobe of liver; ; spleen; ; placenta; ; lip; ; thymus; ; zygote; ; decidua; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; calcium ion binding; nuclease activity; endonuclease activity; endodeoxyribonuclease activity; hydrolase activity; deoxyribonuclease activity; deoxyribonuclease I activity;
Cellular component	extracellular region; endoplasmic reticulum; nucleus;
Biological process	DNA metabolic process; DNA catabolic process; programmed cell death involved in cell development; apoptotic process; programmed cell death; apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic; neutrophil activation involved in immune response; regulation of acute inflammatory response; regulation of neutrophil mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	1776
	13421
	ENSG00000163687
	ENSMUSG00000025279
	Q13609
	O55070
	NM_004944; NM_001256560
	NM_007870
	NP_001243489; NP_004935
	NP_031896
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyribonuclease gamma (also termed DNase γ, deoxyribonuclease 1L3, DNASE1L3, of deoxyribonuclease I like 3) is an enzyme that in humans is encoded by the DNASE1L3 (also termed the deoxyribonuclease 1L3 or deoxyribonuclease 1 like 3) gene. This gene's is located on chromosome 3's "p arm", i.e., short arm, between region 1, band 4, sub-band 3 and region 2, band 1, sub-band 1 (this location's is abbreviation as 3p14.3-p21.1)