DNA polymerase eta

POLH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I5O, 4RNM, 4J9O, 4YQW, 4YR0, 4ECX, 4ECS, 4ECT, 2LSK, 4DL5, 4ECR, 4DL3, 4J9K, 3MR5, 4J9N, 3SI8, 4YP3, 4O3N, 5EWE, 4ECU, 4DL6, 3MR6, 4RNN, 3MR3, 4ECY, 4O3P, 4RNO, 4ECQ, 4O3O, 4O3S, 4ECV, 4J9P, 4Q8F, 4ED3, 4ECZ, 4DL2, 4ECW, 3WUP, 5EWF, 4ED7, 4YR2, 4EEY, 4ED8, 4J9S, 3JAA, 4J9M, 4J9Q, 3MR2, 3TQ1, 4ED6, 4DL7, 4J9R, 4ED0, 4YR3, 4O3Q, 4ED1, 4J9L, 4DL4, 4O3R, 4RU9, 5EWG, 4ED2, 4Q8E, 5KG6, 5DGB, 5KFT, 5DG8, 5KFV, 5KFH, 5KG7, 5KG0, 5KFN, 5KFZ, 5KG1, 5KFX, 5KFC, 5KFU, 5KFA, 5KFK, 5KFI, 5KG4, 5KFQ, 5KFO, 5KFE, 5KFD, 5KFG, 5KG2, 5KFR, 5KFP, 5KG3, 5KFM, 5KFW, 5DGA, 5KFB, 5DG7, 5KFF, 5KFJ, 5DG9, 5L9X, 5KG5, 5KFS, 5KFL, 5KFY
Identifiers
Aliases	POLH, RAD30, RAD30A, XP-V, XPV, DNA polymerase eta, polymerase (DNA) eta
External IDs	OMIM: 603968; MGI: 1891457; HomoloGene: 38189; GeneCards: POLH; OMA:POLH - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,620,523 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,513,571 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Skeletal muscle tissue of rectus abdominis; ; stromal cell of endometrium; ; trabecular bone; ; lower lobe of lung; ; epithelium of colon; ; nipple; ; tonsil; ; tail of epididymis; ; ventricular zone;
	Top expressed in
	endothelial cell of lymphatic vessel; ; spermatocyte; ; Paneth cell; ; cumulus cell; ; body of femur; ; lumbar spinal ganglion; ; fossa; ; mesenteric lymph nodes; ; human fetus; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; metal ion binding; damaged DNA binding; protein binding; DNA-directed DNA polymerase activity;
Cellular component	nucleoplasm; nucleus; cytosol; replication fork; site of double-strand break;
Biological process	DNA synthesis involved in DNA repair; pyrimidine dimer repair; DNA biosynthetic process; postreplication repair; error-free translesion synthesis; regulation of DNA repair; cellular response to DNA damage stimulus; DNA replication; cellular response to UV-C; translesion synthesis; response to UV-C; DNA repair; response to radiation; error-prone translesion synthesis;
	Sources:Amigo / QuickGO
Orthologs
	5429
	80905
	ENSG00000170734
	ENSMUSG00000023953
	Q9Y253
	Q9JJN0
	NM_001291969; NM_001291970; NM_006502
	NM_030715; NM_001364947
	NP_001278898; NP_001278899; NP_006493
	NP_109640; NP_001351876
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene.

DNA polymerase eta is a eukaryotic DNA polymerase involved in the DNA repair by translesion synthesis. The gene encoding DNA polymerase eta is POLH, also known as XPV, because loss of this gene results in the disease xeroderma pigmentosum. Polymerase eta is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet radiation or UV.