DNMT1

DNMT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YOC, 3EPZ, 3PTA, 3SWR, 4WXX
Identifiers
Aliases	DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1
External IDs	OMIM: 126375; MGI: 94912; HomoloGene: 124071; GeneCards: DNMT1; OMA:DNMT1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,231,286 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,871,184 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; sural nerve; ; ventricular zone; ; ganglionic eminence; ; bone marrow cells; ; appendix; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; Achilles tendon;
	Top expressed in
	primary oocyte; ; tail of embryo; ; genital tubercle; ; secondary oocyte; ; zygote; ; urethra; ; paramesonephric duct; ; Paneth cell; ; somite; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; DNA binding; transferase activity; promoter-specific chromatin binding; methyl-CpG binding; zinc ion binding; DNA-methyltransferase activity; chromatin binding; metal ion binding; protein binding; RNA binding; DNA (cytosine-5-)-methyltransferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	pericentric heterochromatin; replication fork; nucleoplasm; heterochromatin; nucleus;
Biological process	C-5 methylation of cytosine; regulation of transcription, DNA-templated; maintenance of DNA methylation; positive regulation of DNA methylation-dependent heterochromatin assembly; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; methylation; DNA methylation; positive regulation of gene expression; negative regulation of gene expression, epigenetic; positive regulation of histone H3-K4 methylation; regulation of cell population proliferation; negative regulation of histone H3-K9 methylation; cellular response to amino acid stimulus; regulation of gene expression; Ras protein signal transduction; negative regulation of transcription, DNA-templated; DNA methylation on cytosine; DNA methylation involved in embryo development; chromatin organization; DNA methylation on cytosine within a CG sequence; negative regulation of gene expression; positive regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell apoptotic process; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching;
	Sources:Amigo / QuickGO
Orthologs
	1786
	13433
	ENSG00000130816
	ENSMUSG00000004099
	P26358
	P13864
	NM_001130823; NM_001379; NM_001318730; NM_001318731
	NM_001199431; NM_001199432; NM_001199433; NM_010066; NM_001314011
	NP_001124295; NP_001305659; NP_001305660; NP_001370
NP_001186360; NP_001186361; NP_001186362; NP_001300940; NP_034196;
	NP_001391614
	Wikidata
View/Edit Human	View/Edit Mouse

DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.