Dedicator of cytokinesis protein 1

DOCK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L4C
Identifiers
Aliases	DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1
External IDs	OMIM: 601403; MGI: 2429765; HomoloGene: 55575; GeneCards: DOCK1; OMA:DOCK1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	127,452,517 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	134,775,368 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; olfactory bulb; ; stromal cell of endometrium; ; sural nerve; ; Achilles tendon; ; inferior ganglion of vagus nerve; ; C1 segment; ; Amygdala; ; subthalamic nucleus;
	Top expressed in
	Paneth cell; ; molar; ; endothelial cell of lymphatic vessel; ; vas deferens; ; mandibular prominence; ; ureter; ; vestibular membrane of cochlear duct; ; stria vascularis; ; maxillary prominence; ; adrenal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity; guanyl-nucleotide exchange factor activity; SH3 domain binding; protein binding;
Cellular component	membrane; guanyl-nucleotide exchange factor complex; cytoplasm; nucleus; cytosol; nuclear speck;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; small GTPase mediated signal transduction; blood coagulation; phagocytosis, engulfment; vascular endothelial growth factor receptor signaling pathway; cytoskeleton organization; phagocytosis; integrin-mediated signaling pathway; cell migration; signal transduction; apoptotic process; positive regulation of GTPase activity; positive regulation of epithelial cell migration; positive regulation of substrate adhesion-dependent cell spreading;
	Sources:Amigo / QuickGO
Orthologs
	1793
	330662
	ENSG00000150760
	ENSMUSG00000058325
	Q14185
	Q8BUR4
	NM_001290223; NM_001380
	NM_001033420
NP_001277152; NP_001371; NP_001364472; NP_001364473; NP_001364475;
	NP_001364476; NP_001364477; NP_001364479; NP_001364482; NP_001364483; NP_001364485; NP_001364487; NP_001364489; NP_001364490
	NP_001028592
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein 1 (Dock1), also (DOCK180), is a large (~180 kDa) protein encoded in the human by the DOCK1 gene, involved in intracellular signalling networks. It is the mammalian ortholog of the C. elegans protein CED-5 and belongs to the DOCK family of guanine nucleotide exchange factors (GEFs).