Dedicator of cytokinesis protein 10

DOCK10
Identifiers
Aliases	DOCK10, DRIP2, Nbla10300, ZIZ3, Dock10, dedicator of cytokinesis 10
External IDs	OMIM: 611518; MGI: 2146320; HomoloGene: 45952; GeneCards: DOCK10; OMA:DOCK10 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	225,042,468 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	80,736,244 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; C1 segment; ; buccal mucosa cell; ; inferior ganglion of vagus nerve; ; spleen; ; granulocyte; ; substantia nigra; ; bone marrow cells; ; subthalamic nucleus;
	Top expressed in
	mesenteric lymph nodes; ; otolith organ; ; utricle; ; lateral septal nucleus; ; spleen; ; globus pallidus; ; sciatic nerve; ; stroma of bone marrow; ; substantia nigra; ; suprachiasmatic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; guanyl-nucleotide exchange factor activity; molecular function;
Cellular component	extracellular exosome; membrane; nucleus; cytoplasm; cell projection; dendritic spine; nucleoplasm; cytosol; intracellular anatomical structure;
Biological process	small GTPase mediated signal transduction; regulation of cell migration; B cell homeostasis; marginal zone B cell differentiation; positive regulation of GTPase activity; dendritic spine morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55619
	210293
	ENSG00000135905
	ENSMUSG00000038608
	Q96BY6
	Q8BZN6
	NM_001290263; NM_014689; NM_017718; NM_001363762
	NM_001285927; NM_175291
	NP_001277192; NP_055504; NP_001350691
	NP_001272856; NP_780500; NP_001393483; NP_001393484
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein 10 (Dock10), also known as Zizimin3, is a large (~240 kDa) protein involved in intracellular signalling networks that in humans is encoded by the DOCK10 gene. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors, which function as activators of small G-proteins.