Dedicator of cytokinesis protein 2

DOCK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RQR, 2YIN, 3A98, 3B13
Identifiers
Aliases	DOCK2, IMD40, Dock2, dedicator of cytokinesis 2
External IDs	OMIM: 603122; MGI: 2149010; HomoloGene: 37984; GeneCards: DOCK2; OMA:DOCK2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	170,083,382 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	34,674,719 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; monocyte; ; granulocyte; ; blood; ; spleen; ; lymph node; ; appendix; ; epithelium of colon; ; trabecular bone; ; thymus;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; spleen; ; thymus; ; stroma of bone marrow; ; blood; ; tibiofemoral joint; ; subcutaneous adipose tissue; ; ankle; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; T cell receptor binding;
Cellular component	cytoplasm; cytosol; membrane; extracellular exosome; cytoskeleton; endomembrane system; extracellular region; specific granule lumen;
Biological process	positive regulation of phagocytosis; small GTPase mediated signal transduction; alpha-beta T cell activation; mitigation of host defenses by virus; membrane raft polarization; negative thymic T cell selection; T cell proliferation; chemotaxis; alpha-beta T cell proliferation; macropinocytosis; cytoskeleton organization; myeloid dendritic cell activation involved in immune response; positive thymic T cell selection; establishment of T cell polarity; immunological synapse formation; actin cytoskeleton organization; T cell activation; positive regulation of GTPase activity; neutrophil degranulation; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	1794
	94176
	ENSG00000134516
	ENSMUSG00000020143
	Q92608
	Q8C3J5
	NM_004946
	NM_033374
	NP_004937
	NP_203538
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein 2 (Dock2) is a protein encoded in the human by the DOCK2 gene. Dock2 is a large (~180 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins. Dock2 specifically activates isoforms of the small G protein Rac.