Dedicator of cytokinesis protein 3

DOCK3
Identifiers
Aliases	DOCK3, MOCA, PBP, Dock3, dedicator of cytokinesis 3, NEDIDHA
External IDs	OMIM: 603123; MGI: 2429763; HomoloGene: 21030; GeneCards: DOCK3; OMA:DOCK3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	51,384,198 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,109,108 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; paraflocculus of cerebellum; ; middle frontal gyrus; ; postcentral gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; superior frontal gyrus; ; cerebellar vermis; ; dorsolateral prefrontal cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; piriform cortex; ; primary motor cortex; ; olfactory tubercle; ; zygote; ; prefrontal cortex; ; cerebellar cortex; ; temporal lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol;
Biological process	small GTPase mediated signal transduction; positive regulation of non-membrane spanning protein tyrosine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	1795
	208869
	ENSG00000088538
	ENSMUSG00000039716
	Q8IZD9
	Q8CIQ7
	NM_004947
	NM_153413
	NP_004938
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein 3 (Dock3), also known as MOCA (modifier of cell adhesion) and PBP (presenilin-binding protein), is a large (~180 kDa) protein encoded in the human by the DOCK3 gene, involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins. Dock3 specifically activates the small G protein Rac.