Dedicator of cytokinesis protein 4

DOCK4
Identifiers
Aliases	DOCK4, Dock4, dedicator of cytokinesis 4
External IDs	OMIM: 607679; MGI: 1918006; HomoloGene: 56680; GeneCards: DOCK4; OMA:DOCK4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	112,206,407 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	40,896,873 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Region I of hippocampus proper; ; external globus pallidus; ; middle frontal gyrus; ; Brodmann area 23; ; corpus callosum; ; frontal pole; ; pars reticulata; ; entorhinal cortex; ; postcentral gyrus;
	Top expressed in
	lateral septal nucleus; ; subiculum; ; hippocampus proper; ; Rostral migratory stream; ; subdivision of hippocampus; ; dentate gyrus; ; Region I of hippocampus proper; ; piriform cortex; ; lobe of cerebellum; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; receptor tyrosine kinase binding; PDZ domain binding; protein binding; guanyl-nucleotide exchange factor activity; GTPase activator activity;
Cellular component	stereocilium bundle; cytoplasm; cytosol; cell projection; membrane; stereocilium; nucleolus; Golgi apparatus; plasma membrane; intracellular anatomical structure;
Biological process	small GTPase mediated signal transduction; cell chemotaxis; negative regulation of vascular associated smooth muscle contraction; positive regulation of GTPase activity; positive regulation of vascular associated smooth muscle cell migration;
	Sources:Amigo / QuickGO
Orthologs
	9732
	238130
	ENSG00000128512
	ENSMUSG00000035954
	Q8N1I0
	P59764
	NM_014705; NM_001363540
	NM_172803
	NP_055520; NP_001350469
	NP_766391
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein 4 (Dock4), is a large (~190 kDa) protein encoded in the human by the DOCK4 gene, involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins. Dock4 activates the small G proteins Rac and Rap1.