Dedicator of cytokinesis protein 6

DOCK6
Identifiers
Aliases	DOCK6, AOS2, ZIR1, Dock6, dedicator of cytokinesis 6
External IDs	OMIM: 614194; MGI: 1914789; HomoloGene: 83291; GeneCards: DOCK6; OMA:DOCK6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,262,524 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,763,931 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; right lung; ; apex of heart; ; upper lobe of left lung; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; skin of leg; ; skin of abdomen; ; subcutaneous adipose tissue; ; gastric mucosa;
	Top expressed in
	interventricular septum; ; tail of embryo; ; lip; ; ascending aorta; ; left lung; ; semi-lunar valve; ; aortic valve; ; left lung lobe; ; internal carotid artery; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity;
Cellular component	perinuclear region of cytoplasm; cytoplasm; cytosol;
Biological process	small GTPase mediated signal transduction; blood coagulation;
	Sources:Amigo / QuickGO
Orthologs
	57572
	319899
	ENSG00000130158
	ENSMUSG00000032198
	Q96HP0
	Q8VDR9
	NM_020812; NM_001367830
	NM_177030
	NP_065863; NP_001354759
	NP_796004
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein 6 (Dock6), also known as Zir1 is a large (~200 kDa) protein encoded in the human by the DOCK6 gene, involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G-proteins.