Dedicator of cytokinesis protein 7

DOCK7
Identifiers
Aliases	DOCK7, EIEE23, ZIR2, Dock7, dedicator of cytokinesis 7, DEE23
External IDs	OMIM: 615730; MGI: 1914549; HomoloGene: 23566; GeneCards: DOCK7; OMA:DOCK7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	62,688,386 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	99,009,152 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; Achilles tendon; ; sural nerve; ; tibia; ; ganglionic eminence; ; retinal pigment epithelium; ; skin of arm; ; cartilage tissue; ; epithelium of colon; ; corpus callosum;
	Top expressed in
	tail of embryo; ; medullary collecting duct; ; secondary oocyte; ; ganglionic eminence; ; genital tubercle; ; renal corpuscle; ; ventricular zone; ; zygote; ; retinal pigment epithelium; ; superior cervical ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; protein binding;
Cellular component	cell projection; focal adhesion; growth cone; basal part of cell; intracellular anatomical structure; axon; neuron projection; COP9 signalosome;
Biological process	cell differentiation; establishment of neuroblast polarity; axonogenesis; activation of GTPase activity; small GTPase mediated signal transduction; interkinetic nuclear migration; nervous system development; positive regulation of peptidyl-serine phosphorylation; multicellular organism development; neuron projection development; regulation of neurogenesis; microtubule cytoskeleton organization; positive regulation of vascular associated smooth muscle cell migration; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	85440
	67299
	ENSG00000116641
	ENSMUSG00000028556
	Q96N67
	Q8R1A4
NM_001271999; NM_001272000; NM_001272001; NM_001272002; NM_033407;
	NM_001330614; NM_001367561
	NM_001290636; NM_026082; NM_001369285; NM_001369286
NP_001258928; NP_001258929; NP_001258930; NP_001258931; NP_001317543;
	NP_212132; NP_001354490
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein (Dock7) is a large (~240 kDa) protein encoded in the human by the DOCK7 gene, involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins. Dock7 activates isoforms of the small G protein Rac.